Answered

The enzyme phosphofructokinase (PFK) catalyzes a key step in glycolysis. About 10% of Springer spaniels suffer from canine PFK deficiency. Given its critical role in glycolysis, which of the following conditions would be a likely consequence for dogs afflicted with this disorder? A) They would die as embryos. B) They would have elevated blood-glucose levels, which may result in a high incidence of diabetes. C) They would be lethargic and readily tire from exercise. D) They would carry out elevated levels of oxidative phosphorylation.

Answer :

The correct option is (C)

Explanation:

  • The third step of Glycolysis is controlled by an enzyme Phosphofructokinase
  • It means, the phosphofructokinase helps in the conversion of fructose-6-phosphate into fructose-1,6-biphosphate(F1,6BP)
  • The phosphate group from ATP to F6P is transfer by Phosphofructokinase
  • This step in glycolysis is the rate limiting step because it is the slowest reaction in glycolysis
  • PFK is inhibited by low pH levels, high levels of ATP, high levels of citrate
  • The increase in the levels of Fructose 2,6 bisphosphate and adenosine monophosphate activate PFK and thus increases the rate of Glycolysis

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