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Biology

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Why are histamine2 receptor antagonists preferred in the treatment of upper gastrointestinal (gi) disorders over traditional histamine1 receptor antagonists?

Answer :

Today at 11:56 AM

I think it is because the Histamine 2 receptor Antagonists inhibit both basal secretion of gastric acid and the secretion stimulated by histamine, acetylcholine, and gastrin. For example, Cimetidine (Tagamet) is the prototype of this class. It inhibits action of histamine at H2 receptors of the stomach, decreasing the amount of acidity, and pepsin content of gastric juices.

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